Modulation of Glucocorticoid Effect in Thymus of Adrenalectomized-Diabetic Rat

Summary

Cellular receptors to glucocorticoids and the effect of dexamethasone and corticosterone on ³H-uridine incorporation into the acid-insoluble fraction were studied in thymocytes from adrenalectomized-diabetic rats and adrenalectomized ones. An increase in the dissociation constant of the hormone-receptor plot was observed when adrenalectomized-diabetic animals were compared to adrenalectomized controls. Meanwhile decreasing concentrations of dexamethasone and corticosterone below receptors saturation, were less active as inhibitor of ³H-uridine incorporation into RNA by thymocytes from adrenalectomized-diabetic than from adrenalectomized ones.

Key-Words:

Adrenalectomized-Diabetic Rats - Thymocytes - Glucocorticoid - Glucocorticoid-Receptors - ³H-Uridine Incorporation