Atrophy of the Thymus in Rats Rendered Diabetic by Streptozotocin

K. Chatamra; P. M. Daniel; M. D. Kendall; D. K. C. Lam

doi:10.1055/s-2007-1013630

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Horm Metab Res 1985; 17(12): 630-632
DOI: 10.1055/s-2007-1013630

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© Georg Thieme Verlag, Stuttgart · New York

Atrophy of the Thymus in Rats Rendered Diabetic by Streptozotocin

K. Chatamra, P. M. Daniel, M. D. Kendall¹ , D. K. C. Lam

¹Departments of Biochemistry and Anatomy St. Thomas's Hospital Medical School, England
Department of Applied Physiology and Surgical Sciences, Royal College of Surgeons, London, England

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Publication History

1984

1984

Publication Date:
14 March 2008 (online)

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Summary

The thymus atrophied rapidly in rats rendered diabetic by a single injection of Streptozotocin. The weight of the gland was reduced to one-fifth of its original weight within three weeks. Histologically there was a great loss of cortical thymocytes and a marked increase in mast cells lying in the thickened fibrous tissue. These findings may have a bearing on the state of immune deficiency observed in animals with diabetes induced by Streptozotocin.

Key-Words:

Thymus - Diabetes - Immune Deficiency