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Horm Metab Res 1985; 17(11): 592-594
DOI: 10.1055/s-2007-1013614
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© Georg Thieme Verlag, Stuttgart · New York

Specific Epidermal Growth Factor Receptors on Porcine and Human Thyroid Membranes

K. Kasai, H. Kuroda, Y. Hashigami, M. Ishikawa, T. Nakamura, S.-I. Shimoda
  • Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
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Publication History

1984

1984

Publication Date:
14 March 2008 (online)

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Summary

Specific, high affinity, saturable receptors for epidermal growth factor (EGF) have been demonstrated both on porcine and on human thyroid membranes. The binding affinities of porcine (Ka 3.0 × 10-9 M) and human thyroid EGF receptors (Ka 1.75 × 10-9 M) are very similar. TSH does not inhibit the binding of 125I-EGF to either membrane. These results suggest the possibility that EGF may be involved in the regulation of human as well as porcine thyroid follicular cell growth and function.

Key-Words:

Thyroid - Epidermal Growth Factor - Receptor - Porcine - Human