PDF icon PDF herunterladen
Horm Metab Res 1985; 17(11): 592-594
DOI: 10.1055/s-2007-1013614
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Specific Epidermal Growth Factor Receptors on Porcine and Human Thyroid Membranes

K. Kasai, H. Kuroda, Y. Hashigami, M. Ishikawa, T. Nakamura, S.-I. Shimoda
  • Department of Endocrinology, Internal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
Weitere Informationen

Publikationsverlauf

1984

1984

Publikationsdatum:
14. März 2008 (online)

Auch verfügbar aufeRef
 als PDF herunterladen  Lizenzen und Reprints
Preview

Summary

Specific, high affinity, saturable receptors for epidermal growth factor (EGF) have been demonstrated both on porcine and on human thyroid membranes. The binding affinities of porcine (Ka 3.0 × 10-9 M) and human thyroid EGF receptors (Ka 1.75 × 10-9 M) are very similar. TSH does not inhibit the binding of 125I-EGF to either membrane. These results suggest the possibility that EGF may be involved in the regulation of human as well as porcine thyroid follicular cell growth and function.

Key-Words:

Thyroid - Epidermal Growth Factor - Receptor - Porcine - Human