The relationship between plasma concentration and disappearance (infusion) rate of
insulin was determined during infusion of insulin via the portal circulation of 14
normal euglycaemic dogs when somatostatin was infused to block endogenous insulin
secretion. The relationship could be represented by one straight line over the plasma
immunoreactive insulin range 0 to 110 μ/ml (r = 0.99) but above 110 μ/ml the fractional
insulin disappearance rate declined. The results indicate the existence in the dog
of a saturable pathway of insulin degradation that could conceivably be located in
liver and which may become saturated only at insulin concentrations in the portal
vein exceeding approximately 330 μ/ml.
Insulin
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Disappearance Rate
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Dog
