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Horm Metab Res 1985; 17(6): 271-274
DOI: 10.1055/s-2007-1013517
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© Georg Thieme Verlag, Stuttgart · New York

Effects of Insulin Treatment on Ketone Body Production and Carnitine-Palmitoyl-Transferase (CPT) Activity in the Isolated Perfused Liver from Streptozotocin Diabetic Rats

P. Tessari, A. Meneghel, A. Avogaro, R. Nosadini, S. Del Prato, A. Tiengo
  • Istituto di Medicina Clinica, Cattedre di Patologia Medica e di Malattie del Ricambio - Policlinico Universitario - Padova, Italy
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Publication History

1983

1984

Publication Date:
14 March 2008 (online)

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Summary

The aim of the present paper was to evaluate the effects of in vivo insulin treatment of Streptozotocin (SZ) diabetic rats on the metabolism of the isolated, perfused liver. Perfused livers from SZ-diabetic rats showed a higher ketone body production and a higher mitochondrial carnitine-palmitoyl-transferase (CPT) activity than controls, while triglyceride (TG) output and free-fatty-acid (FFA) uptake were significantly reduced.

In vivo insulin treatment normalized both the ketogenic capacity of the liver and CPT activity, while FFA uptake and TG production were still lower than in controls. A significant correlation was found between total ketone body output and CPT activity.

We suggest that In vivo insulin treatment of SZ-diabetic rats can modulate the ketogenic capacity of the isolated, perfused liver.

Key-Words:

Experimental Diabetes - Perfused Rat Liver - Ketone Body Production - Carnitine Palmitoyl Transferase Activity

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