Zinc Metabolism during Captopril Treatment

H. Zumkley; H. P. Bertram; H. Vetter; H. Zidek; H. Losse

doi:10.1055/s-2007-1013508

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Horm Metab Res 1985; 17(5): 256-258
DOI: 10.1055/s-2007-1013508

Clinical

Zinc Metabolism during Captopril Treatment

H. Zumkley, H. P. Bertram, H. Vetter, H. Zidek, H. Losse

Medizinische Universitäts-Poliklinik Münster, Münster, Germany

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Publication History

1983

1984

Publication Date:
14 March 2008 (online)

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Summary

In 14 hypertensives the effect of captopril (angiotensin-converting enzyme inhibitor) treatment on red blood cell Na⁺, K⁺, Mg²⁺ and Zn²⁺ concentrations and on plasma Zn²⁺ concentrations were studied. Intraerythrocytic Zn²⁺ concentrations increased slightly, whereas plasma zinc concentrations decreased. The concurrence of hypozincemia with side effects resembling the symptoms of zinc deficiency such as loss of smell and taste suggests a role of alterations in zinc metabolism for the pharmacodynamics of captopril.

Key-Words:

Angiotensin Convening Enzyme Inhibitor - Zinc - Side Effects