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DOI: 10.1055/s-2007-1013459
© Georg Thieme Verlag, Stuttgart · New York
Urinary Excretion of Unconjugated and Conjugated 3,5-Diiodothyronine
Publication History
1983
1983
Publication Date:
14 March 2008 (online)

Summary
A radioimmunoassay for the estimation of 3,5-diiodothyronine (3,5-T2) in human urine has been established. The urinary excretion of both glucuronide and sulfate conjugates of 3,5-T2 were estimated after enzymatic deconjugation. In 19 healthy controls the median excretion of unconjugated 3,5-T2 was 276 pmol/d, whereas the median excretion of glucuronidated and sulfated 3,5-T2 in 7 healthy subjects was 448 and 451 pmol/d, respectively. The median excretion of 154 pmol/d in 9 hypothyroid patients did not differ from that found in controls. In contrast 12 patients with hyperthyroidism had an enhanced excretion, 1312 pmol/d (P < 0.01). Compared with previous data on the daily degradation of 3,5-T2, it is concluded that approximately onesixth of degradated 3,5-T2 is excreted in the urine.
Key-Words:
Urinary Excretion - 3,5-Diiodothyronine - Conjugates