Summary
To determine whether elevated thyroid hormone is responsible for increased serum angiotensin
converting enzyme in hyperthyroidism, 5 to 40 μg of 3,5,3'-triiodo-L-thyronine was
administered orally and subcutaneously to female Swiss-Webster mice. Serum angiotensin
converting enzyme was significantly increased in all animals given triiodothyronine
compared to controls. Lung and kidney enzymes were moderately reduced in specific
activity but unchanged in total activity due to increase in size of these organs.
The results indicate that in hyperthyroidism, elevated thyroid hormone per se rather than the disease of the thyroid is responsible for elevated serum angiotensin
converting enzyme.
Key-Words:
Mouse
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Hyperthyroidism
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Triiodothyronine
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Angiotensin Converting Enzyme
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Serum
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Lung
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Kidney
