Summary
This study aimed at evaluating the influence of sparteine sulfate either upon basal
plasma glucose and insulin or glucose-induced insulin secretion in normal man.
Thirteen overnight fasted volunteers took part in this study; five of them were submitted
to sparteine sulfate bolus (15 mg in 10 ml of saline solution) followed by a slow
infusion (90 mg/100 ml × 60 min) and eight subjects underwent two different glucose
pulses (20 gr. i.v.) in absence or in presence of sparteine, infused as described
above.
In basal conditions, along with sparteine infusion, plasma glucose showed a progressive
and significant decrease (P < 0.0001) and plasma insulin was significantly higher
from min 10 to 120′ (P < 0.0005-0.001).
Even during the glucose-induced insulin secretion, in the presence of sparteine infusion,
plasma glucose levels were significantly lower while plasma insulin levels were significantly
higher when compared to those observed after glucose alone. The acute insulin response
(AIR) was 42±10 μU/ml after glucose alone vs 67±9 μU/ml after glucose plus sparteine
(P < 0.05). Total insulinemic areas were significantly different being 1410 ± 190
vs 2250 ± 310 μU/ml/min (P < 0.001) during glucose and glucose plus sparteine infusion,
respectively.
This study thereby, demonstrates that in normal man sparteine sulfate, administrated
by intravenous infusion, is able to increase either basal or glucose-induced insulin
secretion.
Key-Words
Sparteine Sulfate
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Insulin Secretion
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Glucose-Induced Insulin Secretion
