Horm Metab Res 1986; 18(7): 476-478
DOI: 10.1055/s-2007-1012350

© Georg Thieme Verlag, Stuttgart · New York

Inhibition of Muscular Triglyceride Lipolysis by Ketone Bodies: A Mechanism for Energy-Preservation in Starvation

M. Wicklmayr, K. Rett, G. Dietze, H. Mehnert
  • III. Medizinische Abteilung Krankenhaus München-Schwabing und Forschergruppe Diabetes, München, Germany
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Publication Date:
14 March 2008 (online)


Using the forearm technique, muscle substrate balances were measured in healthy volunteers under the influence of a low dose intraarterial infusion of β-hydroxybutyrate. The ketone body led to a prompt cessation of muscular release of glycerol and free fatty acids, indicating inhibited muscular triglyceride lipolysis. This finding confirms the concept of substrate regulation of muscle triglyceride lipolysis in vivo.