Inhibition of Muscular Triglyceride Lipolysis by Ketone Bodies: A Mechanism for Energy-Preservation in Starvation

Summary

Using the forearm technique, muscle substrate balances were measured in healthy volunteers under the influence of a low dose intraarterial infusion of β-hydroxybutyrate. The ketone body led to a prompt cessation of muscular release of glycerol and free fatty acids, indicating inhibited muscular triglyceride lipolysis. This finding confirms the concept of substrate regulation of muscle triglyceride lipolysis in vivo.

Key-Words

Human Forearm - Substrate Metabolism - Muscle Metabolism - Lipolysis - Ketone Bodies