PDF herunterladen
Horm Metab Res 1986; 18(7): 446-449
DOI: 10.1055/s-2007-1012342
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Rat Acetoacetate Decarboxylase: Its Role in the Disposal of 4C-Ketone Bodies by the Fetus

F. J. López-Soriano, J. M. Argilés
  • Fisiologia General, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Weitere Informationen

Publikationsverlauf

1985

1985

Publikationsdatum:
14. März 2008 (online)

Auch verfügbar auf
  als PDF herunterladen  Lizenzen und Reprints

Summary

21-day pregnant rats show high tissular and plasmatic acetone concentrations when submitted to a 48-hr fast. This rise is, in fact, associated with an enhanced placental and fetal acetoacetate decarboxylase activity. We propose that acetone formation by the fetus could be a mechanism for pH maintenance and that acetoacetate decarboxylase can play a significant role in the handling of 4C-ketone bodies under conditions in which the substrate concentration cannot easily be controlled by other physiological mechanisms.

Key-Words

Acetoacetate Decarboxylase - Rat - Gestation - Acetone - Fetus

      >