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© Georg Thieme Verlag, Stuttgart · New York
Rat Acetoacetate Decarboxylase: Its Role in the Disposal of 4C-Ketone Bodies by the Fetus
14 March 2008 (online)
21-day pregnant rats show high tissular and plasmatic acetone concentrations when submitted to a 48-hr fast. This rise is, in fact, associated with an enhanced placental and fetal acetoacetate decarboxylase activity. We propose that acetone formation by the fetus could be a mechanism for pH maintenance and that acetoacetate decarboxylase can play a significant role in the handling of 4C-ketone bodies under conditions in which the substrate concentration cannot easily be controlled by other physiological mechanisms.
Acetoacetate Decarboxylase - Rat - Gestation - Acetone - Fetus