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Horm Metab Res 1986; 18(1): 69
DOI: 10.1055/s-2007-1012229
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© Georg Thieme Verlag, Stuttgart · New York

Effect of 1,25(OH)2D3 on the TSH Secretion from Rat Pituitary Cells

K. Törnquist, C. Lamberg-Allardt
  • Endocrine Research Laboratory, University of Helsinki, Helsinki, Finland
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Publikationsverlauf

1985

1985

Publikationsdatum:
14. März 2008 (online)

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Summary

1,25(OH)2D3 slightly increases basal TSH in the incubation media after a 24 h incubation with increasing amounts of the hormone. The TRH induced TSH response increased significantly in the presence of 10-8 M 1,25(OH)2D3 (P < 0.05). The intracellular concentration of TSH after the TRH test showed a slight decreasing tendency after a 24 h incubation with increasing amounts of 1,25(OH)2D3. The presence of verapamil (10-8 M) and propranolol (10-8 M) blunted the enhancing effect of 1,25 (OH)2D3. The results indicate an effect of 1,25 (OH)2D3 on the secretion of TSH.

Key-Words

Vitamin D3 - TSH - TRH