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Horm Metab Res 1986; 18(1): 31-33
DOI: 10.1055/s-2007-1012218
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© Georg Thieme Verlag, Stuttgart · New York

Relationship between Release of LH and Incorporation of Tritiated Thymidine in the Anterior Pituitary Gland of the Castrated Male Rat: Effect of LHRH and its Highly Active Analogue Buserelin

M. I. Romano, G. A. Machiavelli, G. E. Alonso, J. A. Burdman
  • Cátedra de Química Biológica Patológica, Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
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Publication History

1984

1984

Publication Date:
14 March 2008 (online)

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Summary

Castration of the adult male rat significantly (P < 0.01) increased the concentration of LH in serum and the incorporation of (3H) thymidine into the pituitary DNA. The administration of a single dose of LHRH or its analogue buserelin stimulated the release of LH but it did not modify (3H) thymidine incorporation.

When multiple doses of LHRH or buserelin were injected, there was a significant (P < 0.01) inhibition of LH release and also the incorporation of (3H) thymidine into the DNA of the anterior pituitary gland was significantly (P < 0.01) diminished.

These observations are compatible with the idea of the close relationship between hormonal release and DNA synthesis in the anterior pituitary gland of the rat.

Key-Words

Pituitary Gland - DNA Synthesis - LHRH - Buserelin

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