Summary
The effect of physical training on insulin and glucagon release in perfused rat pancreas
was examined in the spontaneously exercised group running in a wheel cage an average
of 1.4 km/day for 3 weeks and in the sedentary control group kept in the cage whose
rotatory wheel was fixed on purpose. Pancreatic immunoreactive insulin (IRI) responses
to glucose and arginine were reduced by 28% and 47.8% respectively in trained rats
compared with untrained rats, while IRI content of the pancreas was similar in these
two groups. The demonstrated decrease in insulin secretion of the β-cell of the trained
rats, in response to the glucose and arginine stimulations, may be functional in nature.
On the other hand, neither pancreatic glucagon immunoreactivity (GI) response to glucose
and arginine nor GI content of the pancreas was modified by exercise training. These
results demonstrate that exercise training reduces IRI responses to glucose as well
as to arginine stimulations, but does not modify any secretory response of pancreatic
GI.
Key-Words
Spontaneous Running
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Blood Sugar
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Arginine Stimulation
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Wheel Cage
