PDF herunterladen
Horm Metab Res 1987; 19(6): 278-279
DOI: 10.1055/s-2007-1011798
SHORT COMMUNICATIONS

© Georg Thieme Verlag, Stuttgart · New York

An Enhanced Serum Prolactin Response to TRH in the Presence of GABA Transaminase Inhibition

S. J. Wroe1 , E. Rimmer1 , G. Kongola1 , R. John2 , R. Henley2 , A. Richens1
  • 1Departments of Pharmacology and Therapeutics, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
  • 2Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
Weitere Informationen

Publikationsverlauf

1986

1987

Publikationsdatum:
14. März 2008 (online)

Auch verfügbar auf
 als PDF herunterladen  Lizenzen und Reprints
Preview

Summary

Patients with epilepsy were found to have an increased 20 minute prolactin response to intravenous TRH stimulation when receiving the GABA-T inhibiting drug vigabatrin. Enhanced GABA activity may either reduce basal prolactin levels whilst allowing a normal pituitary response to TRH stimulation, or may overcome the inhibitory effects of dopamine on pituitary prolactin release.