Whole Body Hyperthermia of Rats Decreases Insulin Binding to Erythrocytes

S. Sasaki; T. Hatayama; T. Ishii; M. Yukioka

doi:10.1055/s-2007-1010863

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1988; 20(8): 481-483
DOI: 10.1055/s-2007-1010863

ORIGINALS

Whole Body Hyperthermia of Rats Decreases Insulin Binding to Erythrocytes

S. Sasaki¹ , T. Hatayama² , T. Ishii¹ , M. Yukioka²

¹Second Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
²Department of Biochemistry, Osaka City University Medical School, Osaka, Japan

Abstract

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Summary

¹²⁵I-insulin binding to rat erythrocytes was studied to investigate the effect of whole body hyperthermia on the insulin receptor. Heat treatment of rats at 42°C for 15 min caused a significant decrease (48.7% of control) in ¹²⁵I-insulin binding to rat erythrocytes. Scatchard analysis showed that the decreased binding resulted from a decrease in the number of the insulin receptors rather than from a decrease in receptor affinity. The decreased receptor number for insulin showed no evidence of recovery, 2 h and 8 h after the hyperthermia. Plasma insulin levels remained lower than the control, up to 8 h after the hyperthermia, whereas plasma glucose, which decreased immediately after the hyperthermia, increased higher than the control, 8 h after the hyperthermia. The low plasma insulin level and decreased number of insulin receptor are believed to be possible factors for the elevation of plasma glucose.

Key-Words

Hyperthermia - Insulin Receptor - Plasma Glucose - Rat

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