The Effect of Thyroxine and Related Compounds on the Aerobic Myeloperoxidase - Catalysed Oxidation of NADH

J. M. Van Zyl; B. J. van der Walt

doi:10.1055/s-2007-1010819

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1988; 20(5): 298-301
DOI: 10.1055/s-2007-1010819

Clinical

The Effect of Thyroxine and Related Compounds on the Aerobic Myeloperoxidase - Catalysed Oxidation of NADH

J. M. Van Zyl, B. J. van der Walt

Department of Pharmacology, University of Stellenbosch Medical School, Tygerberg, South Africa

Abstract

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Summary

Thyroxine concentrations as low as 1 μM significantly stimulate compound III formation during aerobic oxidation of NADH by highly purified myeloperoxidase. This increased compound III formation is parallelled by an increased oxidation of NADH. Stimulation by various thyronine and tyrosine analogues was in the order T₄ > T₃ > 3,5-T₂ (or triiodothyropropionic acid). Thyronine and diiodotyrosine had no significant effect. From the potencies of the various thyronines to stimulate compound III formation, the following structural features seem necessary:

(1) Substitution of thyronine with four iodine atoms.

(2) An amino group on the alanine side chain.

(3) Both aromatic rings of thyronine.

Key-Words

Myeloperoxidase - Aerobic Oxidation of NADH - Thyroxine - Compound

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