We have presented evidence suggesting that the suprachiasmatic nucleus (SCN) is involved
in central regulation of glucose homeostasis. To elucidate this role of the SCN, we
examined the effects of its electrical stimulation on glucose metabolism in male Wistar
rats. During and shortly after this stimulation, we observed hyperglycemia associated
with enhanced hyperglucagonemia but no immediate hyperinsulinemia. In addition, we
detected significant increase in liver glycogen phosphorylase a activity and significant decrease in the liver glycogen content. These findings suggest
that the SCN is important in control of glucose homeostasis through effects on glucagon
and insulin secretions and liver glycogen metabolism.
Suprachiasmatic Nucleus
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Hyperglycemia
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Insulin
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Glucagon
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Glycogen Phosphorylase
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Glycogen
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Rat
