Endoscopy 1992; 24(6): 585-587
DOI: 10.1055/s-2007-1010550
Original Articles

© Georg Thieme Verlag KG Stuttgart · New York

A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Topical Anaesthesia of the Pharynx in Upper Gastrointestinal Endoscopy

J. L. Hedenbro, M. Ekelund, O. Jansson, A. Lindblom
  • Endoscopy Unit, Department of Surgery, Lund University, Lund, Sweden
Further Information

Publication History

Publication Date:
17 March 2008 (online)


Reduction of discomfort during diagnostic upper endoscopy may not be desired by patients if the medication has long-lasting and severe after-effects. The present study was designed to examine whether topical anaesthesia of the pharynx without concomitant sedation is of overall benefit to patients undergoing diagnostic upper endoscopy. Two hundred out-patients were randomized to receive in the form of a pharyngeal spray either 80-120 mg lidocaine or placebo. Patients assessed discomfort on a 100 mm visual analogue scale the day after examination. Patients undergoing endoscopy who received lidocaine spray experienced significantly less discomfort from the intubation (p = 0.0001), and discomfort induced by the rest of the examination was also reduced (p = 0.003). The outcome of the endoscopists' assessment was also in favour of lidocaine spray for intubation (p = 0.157) and ease of examination (p = 0.0014). The assessment of throat discomfort suffered by patients after endoscopy did not differ between the groups. A majority of patients, the same proportion in each group, stated they would prefer their next endoscopy to be performed with topical anaesthesia.