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DOI: 10.1055/s-2007-1009224
© Georg Thieme Verlag, Stuttgart · New York
A Comparison of Metformin Versus Guar in Combination with Sulphonylureas in the Treatment of Non Insulin Dependent Diabetes
Publication History
1987
1988
Publication Date:
14 March 2008 (online)

Summary
Twelve non-obese non insulin dependent diabetics whose mean ± SE fasting blood glucose was 12.9 ± 0.9 mmol/l despite maximal doses of sulphonylureas, received 8 weeks of guar (5 g tid before meals) and 8 weeks of metformin (0.5 g tid) following a six week washout period, in a cross-over design. Guar significantly lowered fasting cholesterol and triglyceride concentrations but did not alter glucose concentrations. Conversely, metformin significantly reduced fasting and post-prandial glucose concentrations but had no influence on plasma lipids.
Key words
Non Insulin Dependent Diabetes - Sulphonylurea - Metformin - Guar - Cholesterol - Glycaemic control