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Horm Metab Res 1989; 21(4): 203-206
DOI: 10.1055/s-2007-1009191
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Zinc: An Inhibitor of Prolactin (PRL) Secretion in Humans

J. Brandão Néto1 , B. B. de Mendonça2 , T. Shuhama3 , J. S. Marchini1 , G. Madureira2 , W. P. Pimenta1 , M. T. T. Tornero4
  • 1Endocrine-Metabolism Units, Departments of Internal Medicine, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil
  • 2Endocrine-Metabolism Units, Departments of Internal Medicine, Universidade de São Paulo (USP), Botucatu, São Paulo, Brazil
  • 3Analytical Chemistry Laboratory, Department of Physical Chemistry, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Botucatu, São Paulo, Brazil
  • 4Department of Biostatistic, Institute of Bioscience, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil
Further Information

Publication History

1987

1988

Publication Date:
14 March 2008 (online)

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Summary

The response of plasma prolactin (PRL) to oral administration of increasing doses of zinc (25.0, 37.5 and 50.0 mg) was studied in 17 normal adult men and women. Blood samples were collected at 10 and 30-min intervals over a period of 120 min after two basal times (-30 and 0 min). PRL concentrations significantly fell below basal levels in all subjects in response to the increase in plasma zinc levels, as compared to the controls.

These results suggest that acute hyperzincemia can inhibit basal PRL secretion in normal individuals.

Key-Words

Zinc - Prolactin (PRL) Release - Hypothalamus - Hypophysis - Normal Individuals