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Horm Metab Res 1989; 21(4): 185-188
DOI: 10.1055/s-2007-1009187
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© Georg Thieme Verlag, Stuttgart · New York

Attenuated Diuretic and Natriuretic Effects of Atrial Natriuretic Peptide in Rats with Heart Failure

Tuula Tikkanen1 , I. Tikkanen1 , H. Sariola2 , Margareta Svartström-Fraser3 , F. Fyhrquist1
  • 1Unit of Clinical Physiology, The Minerva Institute for Medical Research
  • 2Department of Pathology, University of Helsinki
  • 3Orion Corporation Ltd., Orion Pharmaceuticals, Helsinki, Finland
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Publikationsverlauf

1988

1988

Publikationsdatum:
14. März 2008 (online)

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Summary

Plasma levels of atrial natriuretic peptide (ANP) and renal responses to ANP were examined in rats with chronic cardiac failure produced by coronary artery ligation and in sham-operated controls. Plasma ANP levels were elevated in the rats with severe cardiac failure as compared with the controls (P < 0.001). ANP injections at the doses of 1, 5, 25 and 50 μg/kg increased water and sodium excretion significantly at all but the lowest dose in the controls; only the two largest doses caused clear diuresis and natriuresis in the heart failure group. The diuretic and natriuretic effects of ANP were significantly weaker at the doses of 5 and 25 μg/kg in the rats with heart failure as compared with the controls. We conclude, that natriuretic and diuretic effects of ANP are attenuated in this chronic heart failure mode.

Key-Words

ANP - Atrial Natriuretic Peptide - Diuretic - Heart Failure - Heart Infarct - Natriuretic - Rat