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DOI: 10.1055/s-2007-1009174
© Georg Thieme Verlag, Stuttgart · New York
Nuclear Thyroid Hormone Receptor Binding in Human Mononuclear Blood Cells after Goitre Resection
Publication History
1987
1988
Publication Date:
14 March 2008 (online)
Summary
Nuclear thyroxine and triiodothyronine receptor-binding in human mononuclear blood cells were examined in 14 euthyroid persons prior to and 1, 6, 24 and 53 weeks after goitre resection. One week after resection decreased serum T3 from 1.47 nmol/l to 1.14 nmol/l (P < 0.05), FT4I from 103 a. u. to 94 a. u. and SHBG from 80 nmol/l to 69 nmol/l (P < 0.05) followed after 6 weeks by a rise in serum TSH from 1.2 mU/l to 11.0 mU/l (P < 0.05) suggesting an initial slight hypothyroidism. Nuclear receptor-binding of T4 and T3 increased within one week and eventually decreased to preresectional values.
We conclude that the expected alteration of the metabolic state caused by resection of the gland is opposed by increased nuclear binding of T4 and T3.
Key-Words
Goitre - Thyroid Resection - Thyroxine Receptors - Triiodothyronine Receptors