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Horm Metab Res 1989; 21(2): 92-95
DOI: 10.1055/s-2007-1009159
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Alpha-Human Atrial Natriuretic Polypeptide Inhibits 19-Hydroxy-Androstenedione Secretion by Human Adrenal Cells

K. Higuchi, H. Nawata, K. Kato, H. Ibayashi
  • Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
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Publikationsverlauf

1987

1988

Publikationsdatum:
14. März 2008 (online)

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Summary

We investigated the effect of ACTH, angiotensin II (AII), and α-human atrial natriuretic polypeptide (α-hANP) which plays an important role of water-electrolytes balance, on 19-hydroxyandrostenedione (19-hydroxyandrost-4-ene-3,17-dione, 19-OH-A-dione)secretion by cultured human adrenal cells. 19-OH-A-dione in culture media was measured using a specific RIA. Basal 19-OH-A-dione secretion by adrenal cells was 0.69 ± 0.08 ng/3h/106 cells and significantly rose to 1.17 ± 0.14 ng/3h/106 cells in the presence of ACTH, but not in the presence of A II. These results demonstrate that 19-OH-A-dione is directly secreted from adrenal cells. α-hANP significantly inhibited both basal and ACTH-stimulated 19-OH-A-dione secretions, as well as aldosterone. These results demonstrate that α-hANP inhibits aldosterone activity by means of the inhibition of both aldosterone and 19-OH-A-dione (an aldosterone amplifier) secretion by adrenal cells.

Key-Words

Atrial Natriuretic Polypeptide - Aldosterone Amplifier

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