The Role of Serum Fructosamine as a Screening Test for Gestational Diabetes Mellitus

Summary

The serum fructosamine concentration indicates the degree of glycation of serum proteins, particularly albumin, and reflects an average blood glucose level over the previous 1-3 weeks. Serum fructosamine, glycated haemoglobin (HbA1c), total serum protein, serum albumin, fasting plasma glucose and oral glucose tolerance test (OGTT) have been measured in 127 healthy control subjects, 102 type 1 and 152 type 2 diabetes mellitus patients and 106 nondiabetic pregnant women. Fructosamine concentration of 2.24 ± 0.16 and 3.21 ± 0.41 mmol/l (mean ± S.D.) has been found in control subjects and diabetics respectively (P < 0.001). During the second trimester a significantly lower fructosamine level (1.92 ± 0.21 mmol/l) has been found in pregnant women, most likely due to the low serum albumin concentration (31.35 ± 3.97 g/l). None of them had a fructosamine level above the normal limit of 2.55 mmol/l. On the other hand, 12 pregnant women showed a disturbed OGTT with normal fructosamine. If the serum fructosamine concentration was adjusted for 40 g/l albumin, then a mean fructosamine of 2.16 ± 0.24 mmol/l was found in patients with gestational diabetes. Our results show that serum fructosamine has a similar diagnostic value as HbA1c for non-pregnant adults, but neither can replace OGTT for the diagnosis of gestational diabetes.

Key-Words

Glycated Proteins - Fructosamine - Type 1 and Type 2 Diabetes Mellitus - Gestational Diabetes - Screening Test