Horm Metab Res 1990; 22(6): 313-318
DOI: 10.1055/s-2007-1004910

© Georg Thieme Verlag, Stuttgart · New York

Sequelae to Acromegaly: Reversibility with Treatment of the Primary Disease

S. A. Lieberman, A. R. Hoffman
  • Department of Medicine, Stanford University School of Medicine and the Medical Service, VA Medical Center, Palo Alto, California, U. S. A.
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Publication History

Publication Date:
14 March 2008 (online)


Acromegalic patients suffer from a number of cardiovascular, metabolic, and rheumatologic problems, and they may also have an increased incidence of malignancy. We reviewed the literature concerning the reversibility of acromegalic complications. Hypertension, myocardial hypertrophy, left ventricular dysfunction and some rheumatologic abnormalities often continue despite successful treatment of the acromegaly. In contrast, glucose intolerance, soft tissue changes, and carpal tunnel syndrome usually resolve when the acromegaly is cured. Studies of the incidence and mortality of cancer in acromegaly are conflicting, but several suggest an increased incidence of colorectal cancer.