Increased Serum Kininase I Activity in Pregnancy Complicated by Pre-Eclampsia

Y. Ito; S. Mizutani; S. Nomura; O. Kurauchi; M. Kasugai; O. Narita; Y. Tomoda

doi:10.1055/s-2007-1004895

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1990; 22(4): 252-255
DOI: 10.1055/s-2007-1004895

Clinical

Increased Serum Kininase I Activity in Pregnancy Complicated by Pre-Eclampsia

Y. Ito, S. Mizutani, S. Nomura, O. Kurauchi, M. Kasugai, O. Narita, Y. Tomoda

Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan

Abstract

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Summary

Serum kininase I activity was measured in normal pregnancy and pre-eclampsia. The mean value in nonpregnant controls was 180±25 (SD) nmol/min/ml. Kininase I activity during normal pregnancy significantly increased after week 14, reaching the highest value (240±20 nmol/min/ml) at weeks 38 and 40. The kininase I activity in pregnancy complicated by severe pre-eclampsia was higher than that in normal pregnancy. The possible role played by elevated kininase I levels in pre-eclampsia was discussed.

Key words

Serum Kininase I - Pre-Eclampsia - Bradykinin - Feto-Placental Circulation

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