Increased Serum Kininase I Activity in Pregnancy Complicated by Pre-Eclampsia

Y. Ito; S. Mizutani; S. Nomura; O. Kurauchi; M. Kasugai; O. Narita; Y. Tomoda

doi:10.1055/s-2007-1004895

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Horm Metab Res 1990; 22(4): 252-255
DOI: 10.1055/s-2007-1004895

Clinical

Increased Serum Kininase I Activity in Pregnancy Complicated by Pre-Eclampsia

Y. Ito, S. Mizutani, S. Nomura, O. Kurauchi, M. Kasugai, O. Narita, Y. Tomoda

Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan

Further Information

Publication History

1989

1989

Publication Date:
14 March 2008 (online)

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Summary

Serum kininase I activity was measured in normal pregnancy and pre-eclampsia. The mean value in nonpregnant controls was 180±25 (SD) nmol/min/ml. Kininase I activity during normal pregnancy significantly increased after week 14, reaching the highest value (240±20 nmol/min/ml) at weeks 38 and 40. The kininase I activity in pregnancy complicated by severe pre-eclampsia was higher than that in normal pregnancy. The possible role played by elevated kininase I levels in pre-eclampsia was discussed.

Key words

Serum Kininase I - Pre-Eclampsia - Bradykinin - Feto-Placental Circulation