Horm Metab Res 1990; 22(3): 175-178
DOI: 10.1055/s-2007-1004877
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Phorbol Myristate Acetate Enhances Adenylate Cyclase Activity in Human Polymorphonuclear Leukocytes

C. Rebut-Bonneton1 , J. Demignon1 , P. Sourbier2
  • 1U 262 INSERM
  • 2U 294 INSERM and Laboratoire d'Hématologie et d'Immunologie CHU Xavier-Bichat Université Paris, Paris, France
Weitere Informationen

Publikationsverlauf

1989

1989

Publikationsdatum:
14. März 2008 (online)

Preview

Summary

The putative role of protein phosphorylation in modulating adenylate cyclase activity in polymorphonuclear neutrophil membranes was assessed using phorbol myristate acetate (PMA) to stimulate the activity of protein kinase C.

PMA was demonstrated to enhance the adenylate cyclase activity stimulated by isoproterenol.