Phorbol Myristate Acetate Enhances Adenylate Cyclase Activity in Human Polymorphonuclear Leukocytes

C. Rebut-Bonneton; J. Demignon; P. Sourbier

doi:10.1055/s-2007-1004877

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Horm Metab Res 1990; 22(3): 175-178
DOI: 10.1055/s-2007-1004877

Clinical

Phorbol Myristate Acetate Enhances Adenylate Cyclase Activity in Human Polymorphonuclear Leukocytes

C. Rebut-Bonneton¹ , J. Demignon¹ , P. Sourbier²

¹U 262 INSERM
²U 294 INSERM and Laboratoire d'Hématologie et d'Immunologie CHU Xavier-Bichat Université Paris, Paris, France

Further Information

Publication History

1989

1989

Publication Date:
14 March 2008 (online)

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Summary

The putative role of protein phosphorylation in modulating adenylate cyclase activity in polymorphonuclear neutrophil membranes was assessed using phorbol myristate acetate (PMA) to stimulate the activity of protein kinase C.

PMA was demonstrated to enhance the adenylate cyclase activity stimulated by isoproterenol.

Key words

Adenylate Cyclase - Polymorphonuclear Leukocytes - Isoproterenol - Protein Kinase C - Formyl - Methionyl - Leucyl - Phenylalanine