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Horm Metab Res 1990; 22(3): 136-140
DOI: 10.1055/s-2007-1004870
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© Georg Thieme Verlag, Stuttgart · New York

Abnormal Ca2+-ATPase Activity in Erythrocytes of Non-Insulin-Dependent Diabetic Rats

J. Levy1 , J. R. Sowers1 , M. B. Zemel1 , 2
  • 1Division of Endocrinology, Metabolism and Hypertension, Wayne State University School of Medicine, Detroit, Michigan, U. S. A.
  • 2Department of Nutrition and Food Science, Wayne State University School of Medicine, Detroit, Michigan, U. S. A.
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Publication History

1988

1989

Publication Date:
14 March 2008 (online)

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Summary

Non-insulin-dependent diabetic (NIDD) rats have an increased Ca2+-ATPase activity in their kidney basolateral membranes. We find that a similar increased activity occurs in erythrocytes of the NIDD animals. This alteration in membrane ATPase activity appears to be specific for the Ca2+-ATPase as (Na+ + K+) and Mg2+-ATPase and Na, K and Mg concentrations in the erythrocyte were not affected by the diabetic condition in these animals. Thus, abnormalities in membrane Ca2+-ATPase activity in the NIDD rats are not restricted to one tissue and appear to be a generalized pathology in the NIDD animals.

Key words

Ca2+-ATPase - Red Blood Cells - Diabetes - Rat