Horm Metab Res 1990; 22(1): 22-24
DOI: 10.1055/s-2007-1004840
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© Georg Thieme Verlag, Stuttgart · New York

Correction by Dexamethasone Treatment of the Altered Lipolytic Cascade Induced by Adrenalectomy in Rat Adipocytes

P. de Mazancourt, J. Giot, Y. Giudicelli
  • Department of Biochemistry, Faculty of Medicine Paris-Ouest, Centre Hospitalier de Poissy, Poissy, France
Further Information

Publication History

1988

1989

Publication Date:
14 March 2008 (online)

Summary

The ability of glucocorticoid-treatment to reverse the metabolic alterations caused by adrenalectomy in rat adipocytes was studied. Correction of the enhanced adenosine antilipolytic effect and of the defect in lipolysis, cyclic AMP and adenylate cyclase responsiveness to guanine nucleotides were all achieved after a 24 h dexamethasone treatment, whereas correction of the defect in β-adrenoceptor-density required a 48 h treatment. The latter treatment, however, failed to reverse the defect in both the adenylate cyclase catalytic activity and protein content per fat cell. These different kinetics of restoration indicate that correction by dexamethasone of the defective cyclic AMP and lipolytic responses on one hand and of the guanine nucleotide control of adenylate cyclase on the other one are two related phenomenoms.