Summary
A device for continuous glucose monitoring in fluids was obtained by combining the
microdialysis technique with a measuring flow chamber of the “Glucosensor Unitec Ulm”
using the GOD method for determining amperometrically blood glucose profiles. The
in vitro experiments demonstrate that the relative recovery of glucose by this device
is inversely related to the flow rate of the microdialysis perfusion fluid, which,
in turn, is inversely related to the response time of the device. The glucose signal
increases linearly with the area of the microdialysis working membrane (r = 0.98),
and with the glucose concentrations of the standard solutions (r > 0.95). The variation
coefficient for repeated measurements is below 8%. The accuracy of the device as demonstrated
by mean measuring deviation ranges between 1 and 3.8%.
Key words
Microdialysis - Electroenzymatic Glucosensor - Biosensor - Glucose Oxidase - Continuous
Glucose Monitoring in Interstitial Cell Fluid
