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Horm Metab Res 1991; 23(10): 486-489
DOI: 10.1055/s-2007-1003735
Clinical

© Georg Thieme Verlag, Stuttgart · New York

7B2, a Possible Marker for Nonfunctioning Pancreatic Islet Cell Tumor

H. Iguchi1 , D. Yasuda1 , Y. Yamada1 , A. Funakoshi1 , H. Wakasugi1 , S. R. Bloom2 , M. Chretien3
  • 1Department of Biochemistry, National Kyushu Cancer Center, Fukuoka, Japan
  • 2Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England
  • 3J. A. de Seve Laboratories of Molecular and Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Canada
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Publication History

1990

1991

Publication Date:
14 March 2008 (online)

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Summary

Plasma 7B2 was measured in 13 patients with pancreatic islet cell tumors, 11 with pancreatic adenocarcinoma and 31 normal subjects as a control. The mean (±SD) concentrations of plasma 7B2 in the normal subjects and the patients with pancreatic islet cell tumors were 67 ± 10 and 1041 ± 1786 pmol/1, respectively, and the value in the patients with pancreatic islet cell tumors was significantly higher than that in the normal subjects (p < 0.01). Elevation of plasma 7B2 over the normal range, defined as less than the mean + 3SD value of those in the normal subjects, was found in 10 of 13 patients with pancreatic islet cell tumors including 4 with nonfunctioning tumor. Plasma 7B2 dropped into the normal range postoperatively in 3 patients with nonfunctioning tumor. Plasma 7B2 concentrations in the patients with pancreatic adenocarcinoma remained in the normal range. These results raise a possibility that 7B2 is a useful marker for pancreatic islet cell tumors, in particular nonfunctioning tumor.

Key words

7B2-Nonfunctioning - Pancreatic - Islet - Marker