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Horm Metab Res 1991; 23(9): 442-445
DOI: 10.1055/s-2007-1003722
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Immunohistochemical Localization of Epidermal Growth Factor Receptor in Leiomyomas from Women Treated with Goserelin Depot

M. Leone, S. Cucuccio, P. L. Venturini, M. Valenzano Menada, M. Messeni Leone1 , L. De Cecco
  • Department of Obstetrics and Gynecology, University of Genoa, Genoa, Italy
  • 1Department of Histology and Embryology, University of Genoa, Genoa, Italy
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Publication History

1990

1991

Publication Date:
14 March 2008 (online)

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Summary

Epidermal growth factor receptors (EGFr) were studied by immunohistochemistry in human myometrium and leiomyomas from women treated with the GnRH agonist (GnRH-a) goserelin.

The results were compared with those obtained from women not treated. Vessel cells of leiomyomas and myometrium were always more immunoreactive than fibrocytes and myocites. In fibroids from treated patients the histochemical score (HSCORE) of vessel cells was always significantly lower (p < 0.001) than in control patients. Our data confirm a role of EGF also in fibroid growth and suggest that, the blood supply reduction associated with the volume reduction of these tumours, consequent to the GnRH-a treatment, could be EGF mediated.

Key words

Fibroids - EGF - Angiogenesis - GnRH Agonist