Eight male patients with insulin-dependent diabetes mellitus (IDDM) without residual
beta-cell function were studied on two occasions in random order. In one experiment
hypoglycemia was induced by a constant rate iv infusion of insulin (0.034 U/kg/h)
during 150 minutes. At the other occasion an identical infusion of insulin was given,
but this time euglycemia was maintained by a variable iv infusion of glucose. Plasma
levels of free insulin were almost identical during the two experiments indicating
that insulin clearance is not influenced by hypoglycemia in patients with IDDM.
Diabetes Mellitus - Hypoglycemia - Insulin Clearance
