Glucogenolytic and Hyperglycemic Effect of 33-49 C-Terminal Fragment of Pancreastatin in the Rat in Vivo

Summary

The effects of the 33-49 C-terminal fragment of pancreastatin on glycogen content, glycemia, insulinemia and glucagonemia were studied in the rat in vivo. It was found that after intramesenteric vein injection of the peptide, the glycogen content of liver decreased compared with control group injected with saline-1 <% BSA. Blood glucose levels were increased by the C-terminal fragment of pancreastatin. This study shows that the 33-49 C-terminal fragment of pancreatasin could play a role in glucose metabolism not mediated by insulin or glucagon.

Key words

Pancreastatin - Glycogen - Insulin - Glucagon - Glucose - Rat