Role of Prostaglandin E2 (PGE2) on the Corticotropin-Releasing Hormone (CRH)-Induced ACTH Release in Healthy Men

S. Zacharieva; A.-M. Borissova; K. Andonova; I. Stoeva; P. Matrozov

doi:10.1055/s-2007-1003327

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Horm Metab Res 1992; 24(7): 336-338
DOI: 10.1055/s-2007-1003327

Clinical

Role of Prostaglandin E₂ (PGE₂) on the Corticotropin-Releasing Hormone (CRH)-Induced ACTH Release in Healthy Men

S. Zacharieva, A.-M. Borissova, K. Andonova, I. Stoeva, P. Matrozov

Institute of Endocrinology and Gerontology, Medical Academy, Sofia, Bulgaria

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Publication History

1991

1991

Publication Date:
24 April 2008 (online)

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Summary

The effect of PGE₂ on ACTH and cortisol responses to CRH was studied in 6 healthy men who received CRH i. v. during either saline or PGE₂ infusions which were started 60 min. before testing. ACTH and cortisol responses to CRH were greater during PGE₂ infusion compared to the control study. The results indicate that PGE₂ positively modulates CRH-induced ACTH secretion.

Key words

Prostaglandin E₂ - Corticotropin Releasing Hormone - ACTH - Healthy Men