Effect of LHRH on Plasma 7B2 in Patients with Gonadotropin-Producing Pituitary Adenomas

H. Iguchi; Reiko Demura; D. Yasuda; H. Wakasugi

doi:10.1055/s-2007-1003246

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1992; 24(1): 31-33
DOI: 10.1055/s-2007-1003246

Clinical

Effect of LHRH on Plasma 7B2 in Patients with Gonadotropin-Producing Pituitary Adenomas

H. Iguchi¹ , Reiko Demura³ , D. Yasuda² , H. Wakasugi²

¹Department of Biochemistry, National Kyusu Cancer Center, Fukuoka, Japan
²Department of Gastroenterology, National Kyusu Cancer Center, Fukuoka, Japan
³Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan

Abstract

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Summary

Plasma immunoreactive (IR)-7B2 was measured in four patients with gonadotropin-producing pituitary adenomas. The basal level of plasma IR-7B2 was elevated in one of the four patients. Hyperresponse of plasma IR-7B2 to LHRH or LHRH/TRH was noted in two patients tested. 7B2 was positively stained in a paraffin-embedded section of gonadotropin-producing pituitary adenoma obtained at surgery. These findings suggest that 7B2 is produced in gonadotropin-producing pituitary adenomas and secreted into the blood stream under certain conditions. 7B2 may be a useful marker for gonadotropin-producing pituitary adenomas.

Key words

7B2 - Pituitary Adenoma - LHRH

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