A new method for continuous measurement of subcutaneous tissue glucose content is
introduced: by combining the microdialysis technique with a wearable amperometric
glucose sensor, a device for continuous glucose measurement in the subcutaneous tissue
was obtained. This device was applied to healthy volunteers (n = 10) over the period
of an oral glucose load and to type I diabetic patients (n = 10) under the conditions
of daily life. Glucose profiles in both healthy and diabetic persons were followed
in the subcutaneous tissue up to 27 hours. This technique will certainly open new
perspectives of monitoring and treating diabetic patients.
Subcutaneous Tissue Glucose - Glucose Sensor - Microdialysis
