To determine the changes of the glucose-induced renin-angiotensin-aldosterone system
in chronic renal disease, a standard oral glucose loading test (75 g) was performed
in patients with chronic glomerulonephritis (CGN) (n = 12) and compared with control
subjects (10). Glucose loading resulted in a significant decrease of serum aldosterone
as well as increases of blood glucose and insulin similarly in both CGN and C. However,
the suppression of aldosterone was statistically milder in CGN than in C (p<0.05).
In contrast, significant elevations of plasma renin activity were observed in CGN
at 60 and 120 min, but not in C after glucose loading. Urinary sodium excretion after
glucose ingestion was lower in CGN than in C. These data demonstrated that the glucose-induced
renin-angiotensin-aldosterone system in patients with chronic renal disease differed
from that in healthy subjects.
Oral Glucose Loading - Insulin - Renin-Angiotensin-Aldosterone System - Potassium
- Chronic Glomerulonephritis
