Planta Med 1987; 53(6): 568-569
DOI: 10.1055/s-2006-962814

© Georg Thieme Verlag Stuttgart · New York

The Effect of Piperine on Pharmacokinetics of Phenytoin in Healthy Volunteers

G. Bano1 , V. Amla1 , R. K. Raina1 , U. Zutshi2 , C. L. Chopra2
  • 1Department of Pharmacology and Therapeutics, Government Medical College, Jammu (Tawi)-180001, India.
  • 2Regional Research Laboratory, Jammu (Tawi), India.
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Publication History


Publication Date:
24 January 2007 (online)


Pharmacokinetics of phenytoin were studied in healthy subjects. In a crossover study five volunteers received either a single oral dose (300 mg) of phenytoin alone or in combination with multiple doses of piperine (20 mg × 7 days) followed by an oral dose of phenytoin. Blood samples were collected at 0.5, 1,2,3,4,8,12,24, and 48 h after drug administration and analysed for phenytoin by the enzyme multiplied immunoassay technique (EMIT). The results obtained revealed that a single daily dose of piperine for 7 days decreased the absorption halflife (P < 0.05), prolonged the elimination halflife (P < 0.01), and produced a higher area under the drug concentration curve (P < 0.05) in comparison to phenytoin alone. It is therefore concluded that piperine on multiple dose administration alters the pharmacokinetic parameters of the antiepileptic.