Planta Med 1987; 53(5): 399-401
DOI: 10.1055/s-2006-962756
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© Georg Thieme Verlag Stuttgart · New York

Antifertility Principle of Dictamnus albus Root Bark

Won Sick Woo, Eun Bang Lee, Sam Sik Kang, Kuk Hyun Shin, Hyung Joon Chi
  • Natural Products Research Institute, Seoul National University, 28 Yun-Kuen-Dong, Chong-No-Ku, Seoul 110, Korea.
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Publication Date:
24 January 2007 (online)


A methanol extract of root bark of Dictamnus albus decreased fertility in rats when administered orally on days 1-10 post-coitum. Hexane, chloroform, butanol, and aqueous fractions from the methanol extract were tested with the result that only the hexane fraction exhibited positive activity. Fractionation of the hexane extract resulted in isolation of fraxinellone as an active principle, which was found not to have an estrogenicity. The timed-dosing experiment revealed that the antifertility activity of fraxinellone appeared to be due to an inhibition of implantation.