In Vitro Amoebicidal Testing of Natural Products; Part 2. Alkaloids Related to Emetine

Alison T. Keene; J. David Phillipson; David C. Warhurst; Michel Koch; Elisabeth Seguin

doi:10.1055/s-2006-962672

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Planta Med 1987; 53(2): 201-206
DOI: 10.1055/s-2006-962672

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In Vitro Amoebicidal Testing of Natural Products; Part 2. Alkaloids Related to Emetine

Alison T. Keene¹ , J. David Phillipson¹ , David C. Warhurst² , Michel Koch³ , Elisabeth Seguin³

¹Department of Pharmacognosy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, WC1N 1AX, U.K.
²Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, University of London, Gower Street, London, WC1, U.K.
³Department de Pharmacognosie de l'Universite Rene Descartes Paris V, U.A. au C.N.R.S. No. 484, Faculte des Sciences Pharmaceutiques et Biologiques, 4 Ave de l'Observatoire, F-75006 Paris, France.

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Publication History

1986

Publication Date:
24 January 2007 (online)

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Abstract

A series of 18 alkaloids with structural similarities to emetine have been tested for their in vitro activity against Entamoeba histolytica (NIH 200) and guinea-pig ear keratinocytes. The alkaloids contain either two benzyltetrahydroisoquinoline, two tetrahydro-β-carboline, or mixed benzyltetrahydroisoquinoline/tetrahydro-β-carboline moieties and are of the emetine, tubulosine, and ochrolifuanine class of alkaloids. The results are discussed on the basis of structure-activity relationships.