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Planta Med 1988; 54(3): 219-221
DOI: 10.1055/s-2006-962408
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© Georg Thieme Verlag Stuttgart · New York

Chemistry and Pharmacology of Gentiana lactea

Daniel Schaufelberger1 , 2 , Kurt Hostettmann1
  • 1Institut de Pharmacognosie et Phytochimie, Ecole de Pharmacie, Université de Lausanne, CH-1005 Lausanne, Switzerland.
  • 2Cancer Research Institute, Arizona State University, Tempe, Arizona 85287, USA.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Flavonoids, secoiridoids, and xanthones of Gentiana lactea (Gentianaceae) were investigated and 14 compounds were identified, among these the previously undescribed 2-C-β-D-glucopyranosyl-1,3,7-trihydroxyxanthone (neolancerin). The known constituents of G. lactea include bellidifolin, bellidifolin-8-O-glucoside, deacetylcentapicrin, demethylbellidifolin, demethylbellidifolin-8-O-glucoside, gentiopicrin, isoorientin, isovitexin, loganic acid, mangiferin, swerchirin, sweroside, and swertiamarin. Xanthones with 1,3,5,8-substitution patterns were tested for inhibition of monoamino oxidase. Bellidifolin (1,5,8-trihydroxy-3-methoxyxanthone) was found to be a strong and selective inhibitor of MAO A in vitro.

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