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Planta Med 1988; 54(2): 122-125
DOI: 10.1055/s-2006-962367
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© Georg Thieme Verlag Stuttgart · New York

The Antimalarial Activity of Spathodea campanulata Stem Bark Extract on Plasmodium berghei berghei in Mice

J. M. Makinde1 , O. O. G. Amusan2 , E. K. Adesogan2
  • 1Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria.
  • 2Department of Chemistry, University of Ibadan, Ibadan, Nigeria.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

The action of extracts of the stem bark of Spathodea campanulata on Plasmodium berghei berghei in mice has been studied. The blood schizontocidal activity of the extracts was studied in early and established infections using chloroquine as the reference drug. The prophylactic action of the extracts was also investigated with pyrimethamine as the standard drug. The hexane and chloroform extracts of the stem bark showed blood schizontocidal action in both the 4-Day test and Rane test. The chloroform extract demonstrated some prophylactic properties while the aqueous extract did not show any significant antimalarial property.