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Planta Med 1988; 54(2): 107-109
DOI: 10.1055/s-2006-962361
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© Georg Thieme Verlag Stuttgart · New York

Centaurea corcubionensis: A Study of its Hypoglycemic Activity in Rats

M. T. Chuclá, M. Lamela, A. Gato, I. Cadavid
  • Department of Pharmacology, Pharmacy and Pharmaceutical Technology. Faculty of Pharmacy. University of Santiago de Compostela. Spain.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Extracts of leaves and flowers of Centaurea corcubionensis Lainz have been assayed for hypoglycemie activity in normo- and hyperglycemic rats. Infusion of an active dose of 5 g/kg lowered blood glucose levels by 16-19% and increased circulating insulin by 27-50%. Heavy release of insulin from islets of Langerhans isolated from rat pancreas was induced by doses of 25, 50, and 100 mg/ml. Infusions induced a significant fall in glycemia levels in rats with glucose-induced hyperglycemia, but had no effect on alloxan-diabetic animals.