Planta Med 1989; 55(6): 536-539
DOI: 10.1055/s-2006-962088

© Georg Thieme Verlag Stuttgart · New York

Chemical Structure and Biological Activity of Water-Soluble Polysaccharides from Cassia angustifolia Leaves

B. M. Müller[1] , J. Kraus, G. Franz
  • Departement of Pharmacy, University of Regensburg, Universitätsstraße 31, D-8400 Regensburg, Federal Republic of Germany
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24. Januar 2007 (online)


The water-soluble polysaccharides from Cassia angustifolia L. leaves were isolated and fractionated. The acidic polysaccharide fraction was separated into two subfractions S1 und S2 consisting of L-rhamnose, L-arabinose, D-galactose, and D-galacturonic acid. Further fractionation of the predominant S1 by GPC gave two fractions S1A and S1B with an average molecular weight of 2 × 106 and 1.5 × 105 d, respectively. Methylation analysis of S1A showed the presence of 1,4-linked galacturonic acid (31.0%), 1,2-linked rhamnose (14.5%), 1,2,4-linked rhamnose (15.8%), 1,3,6-linked galactose (15.3%), smaller amounts of 1,3-linked arabinose, 1,5-linked arabinose, and terminal galactose and arabinose residues. Mild acid hydrolysis of S1A indicated that the backbone consists of 1,4-linked galacturonic acid and 1,2-linked rhamnose residues in the ratio of 1:1. Every second rhamnose is connected via C-4 to arabinogalactan sidechains.

The antitumor activity of the polysaccharide fractions was tested against the solid Sarcoma-180 in CD1 mice. Only S1A exhibited a significant antitumor activity with an inhibition rate of 51%.

1 Part of a doctoral thesis