Wirkung eines Alkaloidextraktes von Symphytum officinale auf menschliche Lymphocytenkulturen

Cornelia Behninger; Gudrun Abel; Erhard Röder; Viktor Neuberger; Waltraud Göggelmann

doi:10.1055/s-2006-962084

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Planta Med 1989; 55(6): 518-522
DOI: 10.1055/s-2006-962084

Papers

Wirkung eines Alkaloidextraktes von Symphytum officinale auf menschliche Lymphocytenkulturen

Studies on the Effect of an Alkaloid Extract of Symphytum officinale on Human Lymphocyte CulturesCornelia Behninger¹ , Gudrun Abel¹ , Erhard Röder² , Viktor Neuberger² , Waltraud Göggelmann³

¹Institut für Botanik und Pharmazeutische Biologie der Universität Erlangen-Nürnberg, Staudtstr.5, D-8520 Erlangen, Federal Republic of Germany
²Pharmazeutisches Institut der Universität Bonn, An der Immenburg 4, D-5300 Bonn-Endenich, Federal Republic of Germany
³Abteilung für Toxikologie der GSF München, Ingolstädter Landstr.1, D-8042 Neuherberg, Federal Republic of Germany

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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

An alkaloid extract of Symphytum officinale was investigated for its chromosome-damaging effect in human lymphocytes in vitro. In concentrations of 1.4 µg/ml and 14 µg/ml the alkaloids had no effect, in concentrations of 140 µg/ml and 1400 µg/ml the alkaloids induced sister chromatid exchanges (SCE) as well as chromosome aberrations. Additionally, the influence of rat liver enzymes (S9) was tested. The SCE-inducing capacity and the clastogenic effect of Symphytum alkaloids was increased by simultaneous application of S9-Mix.