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DOI: 10.1055/s-2006-962084
© Georg Thieme Verlag Stuttgart · New York
Wirkung eines Alkaloidextraktes von Symphytum officinale auf menschliche Lymphocytenkulturen
Studies on the Effect of an Alkaloid Extract of Symphytum officinale on Human Lymphocyte CulturesPublikationsverlauf
1988
Publikationsdatum:
24. Januar 2007 (online)

Abstract
An alkaloid extract of Symphytum officinale was investigated for its chromosome-damaging effect in human lymphocytes in vitro. In concentrations of 1.4 µg/ml and 14 µg/ml the alkaloids had no effect, in concentrations of 140 µg/ml and 1400 µg/ml the alkaloids induced sister chromatid exchanges (SCE) as well as chromosome aberrations. Additionally, the influence of rat liver enzymes (S9) was tested. The SCE-inducing capacity and the clastogenic effect of Symphytum alkaloids was increased by simultaneous application of S9-Mix.