Planta Med 1989; 55(5): 423-428
DOI: 10.1055/s-2006-962057

© Georg Thieme Verlag Stuttgart · New York

Mechanisms of Hypoglycemic Activity of Ganoderan B: A Glycan of Ganoderma lucidum Fruit Bodies1

Hiroshi Hikino[2] , Misae Ishiyama, Yutaka Suzuki, Chohachi Konno
  • Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
1 Antidiabetes drugs, Part 33. Also Part 135 in the series on the validity of the Oriental medicines
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Publication History


Publication Date:
24 January 2007 (online)


Ganoderan B increased the plasma insulin level in normal and glucose-loaded mice but elicited no effect on insulin binding to isolated adipocytes. Administration of ganoderan B elicited significant increases of the activities of hepatic glucokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase, decreased the hepatic glucose-6-phosphatase and glycogen synthetase activities and did not affect the activities of hexokinase and glycogen phosphorylase. Ganoderan B reduced the glycogen content in the liver but had no influence on total cholesterol and triglyceride levels in the plasma and liver.

1 Deceased, December 8, 1988